Using stereotactic brain atlases for small rodents and nonhuman primates for optrode array customization

Ronald W. Boutte; Sam Merlin; Brandon Griffiths; Trent Parry; Steve Blair

doi:10.1117/12.2251601

20 February 2017 Using stereotactic brain atlases for small rodents and nonhuman primates for optrode array customization

Ronald W. Boutte, Sam Merlin, Brandon Griffiths, Trent Parry, Steve Blair

Author Affiliations +

Proceedings Volume 10052, Optogenetics and Optical Manipulation; 1005204 (2017) https://doi.org/10.1117/12.2251601
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

As the optogenetic field expands its need to target with high specificity only grows more crucial. This work will show a method for customizing soda-lime glass optrode arrays so that fine structures within the brains of small rodents and nonhuman primates can be optically interrogated below the outer cortical layer. An 8 × 6 array is customized for optrode length (400 μm ), optrode width (75 μm ), optrode pitch (400 μm ), backplane thickness (500 μm ), and overall form factor (3.45 mm × 2.65 mm ). The 400 μm long optrode is capable of illuminating the cortical Layer IV of rhesus macaque ( Macaca Fascicularis ) and the motor cortex of small mice ( Mus Musculus ).

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Citation Download Citation

Ronald W. Boutte, Sam Merlin, Brandon Griffiths, Trent Parry, and Steve Blair "Using stereotactic brain atlases for small rodents and nonhuman primates for optrode array customization", Proc. SPIE 10052, Optogenetics and Optical Manipulation, 1005204 (20 February 2017); https://doi.org/10.1117/12.2251601

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