3-compartment dynamic model of talaporfin sodium pharmacokinetics in silico

Emiyu Ogawa; Yuko Uno; Keishi Ohtani M.D.; Sachio Maehara M.D.; Kentaro Imai; Shotaro Ono; Jitsuo Usuda M.D.; Tsunenori Arai

doi:10.1117/12.2250716

8 February 2017 3-compartment dynamic model of talaporfin sodium pharmacokinetics in silico

Emiyu Ogawa, Yuko Uno, Keishi Ohtani M.D., Sachio Maehara M.D., Kentaro Imai, Shotaro Ono, Jitsuo Usuda M.D., Tsunenori Arai

Author Affiliations +

Proceedings Volume 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI; 100470Y (2017) https://doi.org/10.1117/12.2250716
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

We studied a 3-compartment dynamic model of talaporfin sodium pharmacokinetics in silico. Drug distribution might change after intravenous injection from plasma to interstitial space and then into myocardial cells. We have developed a new cardiac ablation using photosensitization reaction with laser irradiation shortly after talaporfin sodium injection. We think that the major cell-killing factor in our cardiac ablation would be an oxidation by singlet oxygen produced in the interstitial space in myocardium with laser irradiation shortly after the photosensitizer administration. So that the talaporfin sodium concentration change in time in the interstitial space should be investigated. We constructed the pharmacokinetics dynamic model composed by 3-compartments, that is, plasma, interstitial space, and cell. We measured talaporfin sodium fluorescence time change in human skin by our developed fluorescence measurement system in vivo. Using the measured concentration data in plasma and skin in human, we verified the calculation accuracy of our in silico model. We compared the simulated transition tendency of talaporfin sodium concentration from interstitial space to cells in our in silico model with the reported uptake tendency using cultured myocardial cell. We identified the transition coefficients between plasma, interstitial space, and cell compartment, and metabolization coefficient from plasma by the fitting with measured data.

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Emiyu Ogawa, Yuko Uno, Keishi Ohtani M.D., Sachio Maehara M.D., Kentaro Imai, Shotaro Ono, Jitsuo Usuda M.D., and Tsunenori Arai "3-compartment dynamic model of talaporfin sodium pharmacokinetics in silico", Proc. SPIE 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, 100470Y (8 February 2017); https://doi.org/10.1117/12.2250716

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