Use of Mueller matrix polarimetry and optical coherence tomography in the characterization of cervical collagen anisotropy

Joseph Chue-Sang; Yuqiang Bai; Susan Stoff; Mariacarla Gonzalez; Jefferson Gomes; Amir Gandjbakhche; Viktor V. Chernomordik; Jessica C. Ramella-Roman

doi:10.1117/12.2250969

2 March 2017 Use of Mueller matrix polarimetry and optical coherence tomography in the characterization of cervical collagen anisotropy

Joseph Chue-Sang, Yuqiang Bai, Susan Stoff, Mariacarla Gonzalez, Jefferson Gomes, Amir Gandjbakhche, Viktor V. Chernomordik, Jessica C. Ramella-Roman

Author Affiliations +

Proceedings Volume 10043, Diagnosis and Treatment of Diseases in the Breast and Reproductive System; 100430U (2017) https://doi.org/10.1117/12.2250969
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Preterm birth (PTB) presents a serious medical heath concern throughout the world. There is a high incidence of PTB in both developed and developing countries ranging from 11%-15%, respectively. Studies have shown there may be numerous precursors to PTB including infections, genetic predisposition, nutrition and various other morbidities which all lead to a premature disorganization in the cervical collagen resulting in the weakening of the structure designed to keep the fetus in utero. The changes in cervical collagen orientation and distribution may prove to be a predictor of PTB. Polarization imaging is an effective means to measure optical anisotropy in birefringent materials such as those rich in collagen as the cervix is. Non-invasive, full-field Mueller Matrix polarimetry (MMP) imaging methodologies and ex-vivo second harmonic generation (SHG) imaging were used to assess cervical collagen content and structure in non-pregnant porcine cervices. The SHG microscopy was used to verify the efficacy of the MMP in assessing changes in collagen orientation.

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Joseph Chue-Sang, Yuqiang Bai, Susan Stoff, Mariacarla Gonzalez, Jefferson Gomes, Amir Gandjbakhche, Viktor V. Chernomordik, and Jessica C. Ramella-Roman "Use of Mueller matrix polarimetry and optical coherence tomography in the characterization of cervical collagen anisotropy", Proc. SPIE 10043, Diagnosis and Treatment of Diseases in the Breast and Reproductive System, 100430U (2 March 2017); https://doi.org/10.1117/12.2250969

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KEYWORDS

Collagen

Cervix

Optical coherence tomography

Polarimetry

Anisotropy

Silicon

Polarization

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