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13 March 2024 Disorder in collagen at the tumor boundary investigated with double Stokes-Mueller polarimetric microscopy
Viktoras Mažeika, Mykolas Mačiulis, Lukas Kontenis, Mehdi Alizadeh, Masood Samim, Serguei Krouglov, Edvardas Žurauskas, Virginijus Barzda
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Proceedings Volume PC12854, Label-free Biomedical Imaging and Sensing (LBIS) 2024; PC128540J (2024) https://doi.org/10.1117/12.3002404
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Collagen has hierarchical structure and often undergoes remodeling at the tumor margin [1]. Polarimetric second harmonic generation (SHG) microscopy can be used to investigate changes in the collagen structure and provide insight into the metastatic progression of cancer. In this work, we apply double Stokes-Mueller polarimetry (DSMP) to investigate the disorder of collagen at the tumor margin. The disorder is analyzed at several levels of spatial organization – texture analysis (gray level co-occurrence matrix (GLCM) method) is applied at the microscopic tissue organizational level, while ultrastructure is analyzed with DSMP to obtain nonlinear susceptibility tensor for each image voxel. This allows to comprehensively investigate the changes occurring in collagen during tumor progression. [1] Winkler, J. et al., “Concepts of extracellular matrix remodelling in tumour progression and metastasis”, Nat Commun 11, 5120 (2020).
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Viktoras Mažeika, Mykolas Mačiulis, Lukas Kontenis, Mehdi Alizadeh, Masood Samim, Serguei Krouglov, Edvardas Žurauskas, and Virginijus Barzda "Disorder in collagen at the tumor boundary investigated with double Stokes-Mueller polarimetric microscopy", Proc. SPIE PC12854, Label-free Biomedical Imaging and Sensing (LBIS) 2024, PC128540J (13 March 2024); https://doi.org/10.1117/12.3002404
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KEYWORDS
Polarimetry
Collagen
Diseases and disorders
Second harmonic generation
Tumors
Cooccurrence matrices
Mueller matrices
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