Rainer J. Beck,1 Ioannis Bitharas,1 Thomas I. Maisey,2 Ryan K. Mathew,2 Andrew J. Moore,1 James Moor,2 Robert R. Thomson,1 David G. Jayne,2 Jonathan D. Shephard1
1Heriot-Watt Univ. (United Kingdom) 2Univ. of Leeds (United Kingdom)
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The successful laser ablation of clinically relevant tissue models by means of picosecond laser pulses is presented. This is a potential alternative to overcoming limitations of conventional tumour-surgery tools in terms of precision and thermal damage. The correlation of high-speed imaging of the ablation process, schlieren imaging of the resulting plume dynamics and a histopathological analysis of the post-process tissue morphology enables optimisation of the tissue removal rate whilst avoiding adverse cavitation effects. This facilitates minimal collateral thermal damage. Effective tissue removal is presented for the epithelial laser ablation of colonic tissue; with translation of this process towards infiltrating brain and head and neck cancer surgery further discussed.
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Rainer J. Beck, Ioannis Bitharas, Thomas I. Maisey, Ryan K. Mathew, Andrew J. Moore, James Moor, Robert R. Thomson, David G. Jayne, Jonathan D. Shephard, "Picosecond laser pulses for precision ablation of cancerous tissue," Proc. SPIE PC12840, Optical Interactions with Tissue and Cells XXXV, PC1284006 (13 March 2024); https://doi.org/10.1117/12.3002935