A computational framework to analyze time and location-dependent NIRS readouts for detecting cytochrome c oxidase

Anastasia Goulopoulos; Michael Alvarez; Heidy Sierra; Walfre Franco

doi:10.1117/12.3003150

19 March 2024 A computational framework to analyze time and location-dependent NIRS readouts for detecting cytochrome c oxidase

Anastasia Goulopoulos, Michael Alvarez, Heidy Sierra, Walfre Franco

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Proceedings Volume PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; PC128220A (2024) https://doi.org/10.1117/12.3003150
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Sepsis is responsible for over 50% of hospital deaths. Changes in mitochondrial redox state can be indicative of cellular and organ function. Therefore, a method to evaluate mitochondrial utilization of oxygen continuously is critical. Cytochrome-c oxidase (CCO) is a mitochondrial enzyme that participates in oxidative phosphorylation and interacts with near-infrared light, potentially yielding an optical indicator of cellular metabolism. In this work, we use a computational framework to study the feasibility of utilizing photoplethysmography (PPG) signals for detecting CCO when HbO2 and Hb are present. We use a 3D Monte Carlo model of light absorption and transport in tissue to generate optical readouts in the form of temporal PPG signals corresponding to different physiological states. Furthermore, a machine learning model is trained to predict the CCO redox state from PPG signals containing different CCO and hemoglobin species concentrations.

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Citation Download Citation

Anastasia Goulopoulos, Michael Alvarez, Heidy Sierra, and Walfre Franco "A computational framework to analyze time and location-dependent NIRS readouts for detecting cytochrome c oxidase", Proc. SPIE PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, PC128220A (19 March 2024); https://doi.org/10.1117/12.3003150

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KEYWORDS

Near infrared spectroscopy

Mitochondria

3D modeling

Oxygen

Signal detection

Oxygenation

Spectroscopy

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