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16 March 2023 FDTD simulation and chemical synthesis of surface-enhanced Raman supraparticles for translatable in vivo Raman imaging (Conference Presentation)
Jung Ho Yu, Emma O. Cruz, Sanjiv S. Gambhir
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Proceedings Volume PC12396, Plasmonics in Biology and Medicine XX; PC1239609 (2023) https://doi.org/10.1117/12.2650989
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Surface-enhanced Raman scattering (SERS) has extended its biomedical application to in vivo preclinical imaging. However, the in vivo SERS imaging requires non-clearable large gold nanoparticles, limiting their translation in humans. Here, we address this problem by creating SERS supraparticles composed of small-sized nanoclusters. First, we performed the FDTD simulation of the supraparticle design, and the maximum enhancement factor of 10^6 was achieved. Second, we chemically synthesized bright supraparticles that enabled in vivo Raman imaging of rodent models. Furthermore, the supraparticles were highly excretable, offering great potential for clinical application of in vivo Raman imaging by replacing non-excretable SERS nanotags.
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Jung Ho Yu, Emma O. Cruz, and Sanjiv S. Gambhir "FDTD simulation and chemical synthesis of surface-enhanced Raman supraparticles for translatable in vivo Raman imaging (Conference Presentation)", Proc. SPIE PC12396, Plasmonics in Biology and Medicine XX, PC1239609 (16 March 2023); https://doi.org/10.1117/12.2650989
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KEYWORDS
In vivo imaging
Raman spectroscopy
Finite-difference time-domain method
Gold
Nanoantennas
Nanoparticles
Biomedical optics
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