FDTD simulation and chemical synthesis of surface-enhanced Raman supraparticles for translatable in vivo Raman imaging (Conference Presentation)

Jung Ho Yu; Emma O. Cruz; Sanjiv S. Gambhir

doi:10.1117/12.2650989

16 March 2023 FDTD simulation and chemical synthesis of surface-enhanced Raman supraparticles for translatable in vivo Raman imaging (Conference Presentation)

Jung Ho Yu, Emma O. Cruz, Sanjiv S. Gambhir

Author Affiliations +

Proceedings Volume PC12396, Plasmonics in Biology and Medicine XX; PC1239609 (2023) https://doi.org/10.1117/12.2650989
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Surface-enhanced Raman scattering (SERS) has extended its biomedical application to in vivo preclinical imaging. However, the in vivo SERS imaging requires non-clearable large gold nanoparticles, limiting their translation in humans. Here, we address this problem by creating SERS supraparticles composed of small-sized nanoclusters. First, we performed the FDTD simulation of the supraparticle design, and the maximum enhancement factor of 10^6 was achieved. Second, we chemically synthesized bright supraparticles that enabled in vivo Raman imaging of rodent models. Furthermore, the supraparticles were highly excretable, offering great potential for clinical application of in vivo Raman imaging by replacing non-excretable SERS nanotags.

Conference Presentation

Citation Download Citation

Jung Ho Yu, Emma O. Cruz, and Sanjiv S. Gambhir "FDTD simulation and chemical synthesis of surface-enhanced Raman supraparticles for translatable in vivo Raman imaging (Conference Presentation)", Proc. SPIE PC12396, Plasmonics in Biology and Medicine XX, PC1239609 (16 March 2023); https://doi.org/10.1117/12.2650989

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