1Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States) 2Ctr. for Devices and Radiological Health, U.S. Food and Drug Administration (United States) 3Univ. of Wisconsin-Milwaukee (United States) 4Massachusetts General Hospital (United States) 5Univ. of Wisconsin-Madison (United States)
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
Vagus nerve stimulation (VNS) yields promising therapeutic benefits but is often limited by off-target effects. Imaging tools that reveal the fascicular organization within the nerve can be used to better direct stimulation energy to the intended target. Here, we demonstrate polarization-sensitive (PS)-OCT imaging of an intact 7.5 cm ex-vivo porcine vagus nerve. The limited OCT penetration depth was overcome by using a dual-scanning microscope configured to simultaneously acquire B-scans from the upper and lower segments of a nerve sample. Three-dimensional maps of the complex fascicular organization in these nerves were generated.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The alert did not successfully save. Please try again later.
Yong-Chul Yoon, Ilyas Saytashev, Rex Chin-Hao Chen, Fernando P. S. Guastaldi, Abigail L. Gregg, Kip A. Luwdig, Daniel X. Hammer, Benjamin J. Vakoc, "Multi-centimeter fascicle tracing in ex-vivo porcine vagus nerve using PS-OCT (Conference Presentation)," Proc. SPIE PC12382, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2023, PC1238207 (15 March 2023); https://doi.org/10.1117/12.2657585