In vivo Raman spectroscopy for sensing esophageal biomolecular changes in children with eosinophilic esophagitis

Ezekiel Haugen; Andrea Locke; Hernan Correa M.D.; Regina Tyree; Girish Hiremath M.D.; Justin Baba; Anita Mahadevan-Jansen

doi:10.1117/12.2650697

6 March 2023 In vivo Raman spectroscopy for sensing esophageal biomolecular changes in children with eosinophilic esophagitis

Ezekiel Haugen, Andrea Locke, Hernan Correa M.D., Regina Tyree, Girish Hiremath M.D., Justin Baba, Anita Mahadevan-Jansen

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Proceedings Volume PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis; PC123730F (2023) https://doi.org/10.1117/12.2650697
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Eosinophilic esophagitis (EoE) is a clinicopathological condition requiring frequent upper endoscopy (EGD) with several biopsies and time-consuming histopathological diagnosis. We acquired in vivo fingerprint and high wavenumber Raman spectra from the esophageal mucosa of children undergoing EGD and assessed the efficacy of this non-obtrusive real-time approach for determining EoE activity. Spectral bands related to lipids (e.g., 1078, 1301, 1440, 2855cm-1), proteins (e.g., 935, 1003, 1342, 2931cm-1), and water (3075-3650cm-1) were found to differentiate between active, inactive, and non-EoE patients. The results from this study indicate that RS is a promising method for point-of-care assessment of EoE.

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Ezekiel Haugen, Andrea Locke, Hernan Correa M.D., Regina Tyree, Girish Hiremath M.D., Justin Baba, and Anita Mahadevan-Jansen "In vivo Raman spectroscopy for sensing esophageal biomolecular changes in children with eosinophilic esophagitis", Proc. SPIE PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis, PC123730F (6 March 2023); https://doi.org/10.1117/12.2650697

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KEYWORDS

Raman spectroscopy

In vivo imaging

Biosensing

Remote sensing

Molecular spectroscopy

Point-of-care devices

Proteins

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