1.7-micron optical coherence tomography angiography (OCTA) for characterization of hereditary hemorrhagic telangiectasia (HHT) lesions

Raksha Sreeramachandra Murthy; Rachel Elsanadi; Yan Li; John Soliman; Li-Dek Chou; Dennis Sprecher; Christopher Hughes; Kristen Kelly; Zhongping Chen

doi:10.1117/12.2650909

9 March 2023 1.7-micron optical coherence tomography angiography (OCTA) for characterization of hereditary hemorrhagic telangiectasia (HHT) lesions

Raksha Sreeramachandra Murthy, Rachel Elsanadi, Yan Li, John Soliman, Li-Dek Chou, Dennis Sprecher, Christopher Hughes, Kristen Kelly, Zhongping Chen

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Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC123670J (2023) https://doi.org/10.1117/12.2650909
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Hereditary Hemorrhagic Telangiectasia (HHT) is an inherited, autosomal dominant, vascular disorder that affects an estimated 1 in 5,000 individuals (approximately 1.5M globally and 62,000 in the USA. It is characterized by the presence of multiple arteriovenous malformations (AVMs). An arteriovenous malformation (AVM) is an abnormal tangle of blood vessels connecting arteries and veins, disrupting normal blood flow and oxygen circulation. This study proposes a high-resolution, non-invasive multifunctional imaging system that combines 1.7um D-OCT/OCTA to accurately interrogate HHT skin lesions, including hands, chest, and tongue. Integrated OCTA and Doppler OCT imaging can provide information on lesion architecture and microvasculature. We use this methodology to interrogate individual lesion morphology, compare mucosal and skin lesions, and ultimately, evaluate the vascular effects of anti-VEGF treatment.

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Raksha Sreeramachandra Murthy, Rachel Elsanadi, Yan Li, John Soliman, Li-Dek Chou, Dennis Sprecher, Christopher Hughes, Kristen Kelly, and Zhongping Chen "1.7-micron optical coherence tomography angiography (OCTA) for characterization of hereditary hemorrhagic telangiectasia (HHT) lesions", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC123670J (9 March 2023); https://doi.org/10.1117/12.2650909

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KEYWORDS

Imaging systems

Optical coherence tomography

Angiography

Skin

Brain

Capillaries

Laser induced plasma spectroscopy

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