Fluorescence conjugated anti-mucin antibodies to target and brightly label colorectal and pancreatic cancer

Kristin E. Cox; Michael A. Turner; Siamak Amirfakhri; Thinzar M. Lwin; Shanglei Liu; Robert M. Hoffman; Surinder K. Batra; Michael Bouvet

doi:10.1117/12.2650520

17 March 2023 Fluorescence conjugated anti-mucin antibodies to target and brightly label colorectal and pancreatic cancer

Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lwin, Shanglei Liu, Robert M. Hoffman, Surinder K. Batra, Michael Bouvet

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Proceedings Volume PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; PC123610I (2023) https://doi.org/10.1117/12.2650520
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Pancreatic cancer and colon cancer metastasis are recalcitrant cancers that are often difficult to detect. Mucin 5AC (MUC5A) and Mucin 4 (MUC4) have been found to be overexpressed in pancreatic and colon cancers, respectively, while having minimal expression in normal tissue. Using Mucin antibodies conjugated to a fluorescent dye, we demonstrate their specific labeling of human derived pancreatic and colon cancers in both subcutaneous and orthotopic mouse models. Tumor-specific fluorescent antibodies are clinically promising tools for improving both oncologic resection and patient survival.

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Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lwin, Shanglei Liu, Robert M. Hoffman, Surinder K. Batra, and Michael Bouvet "Fluorescence conjugated anti-mucin antibodies to target and brightly label colorectal and pancreatic cancer", Proc. SPIE PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, PC123610I (17 March 2023); https://doi.org/10.1117/12.2650520

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KEYWORDS

Pancreatic cancer

Luminescence

Colorectal cancer

Mouse models

Tumors

Cancer

Colon

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