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Infrared (IR) inhibition can induce selective heat block on small-diameter axons. We hypothesize that the selective IR inhibition effect can be reproduced by resistance heating via a heating cuff. We tested the hypothesis in vitro on the pleural-abdominal connective of Aplysia californica. The IR optical fiber, heating cuff, and a thermocouple were co-located to ensure both heating modalities induced a similar temperature increase on the nerve. Electrically stimulated compound action potentials were recorded and segmented to characterize the inhibition effect on different axonal subgroups. The dose-response curve showed that resistance heating can reproduce the selective IR inhibition effect.
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Junqi Zhuo, Chloe E. Weidrick, Yehe Liu, Michael A. Moffitt, E. Duco Jansen, Hillel J. Chiel, Michael W. Jenkins, "Selective IR inhibition can be reproduced by resistance heating," Proc. SPIE PC11947, Optogenetics and Optical Manipulation 2022, PC1194706 (7 March 2022); https://doi.org/10.1117/12.2610130