Noncontact optical assessment of disrupted cerebral functional connectivity in a piglet model of transient ischemic stroke

Mehrana Mohtasebi; Lei Chen; Siavash Mazdeyasna; Dara Singh; Xuhui Liu; Chong Huang; Samaneh Rabienia Haratbar; Faraneh Fathi; David K. Powell; Kathryn Saatman; Qiang Cheng; Guoqiang Yu

doi:10.1117/12.2609144

7 March 2022 Noncontact optical assessment of disrupted cerebral functional connectivity in a piglet model of transient ischemic stroke

Mehrana Mohtasebi, Lei Chen, Siavash Mazdeyasna, Dara Singh, Xuhui Liu, Chong Huang, Samaneh Rabienia Haratbar, Faraneh Fathi, David K. Powell, Kathryn Saatman, Qiang Cheng, Guoqiang Yu

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Proceedings Volume PC11945, Clinical and Translational Neurophotonics 2022; PC1194505 (2022) https://doi.org/10.1117/12.2609144
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

An innovative camera-based speckle contrast diffuse correlation tomography (scDCT) technology has been developed recently, which enables noncontact, noninvasive, high-density, 3D imaging of cerebral blood flow (CBF) distributions. This study demonstrated the capability and safety of scDCT technique for imaging of CBF distributions in a neonatal piglet model of transient ischemic stroke. Moreover, power spectral density analyses of low-frequency oscillations (LFOs) and the network connections over the brain were assessed before and after the induction of acute ischemic stroke. The stroke resulted in a substantial decrease in CBF, attenuations in resting-state LFOs, and functional connectivity disruptions in motor and somatosensory cortices.

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Mehrana Mohtasebi, Lei Chen, Siavash Mazdeyasna, Dara Singh, Xuhui Liu, Chong Huang, Samaneh Rabienia Haratbar, Faraneh Fathi, David K. Powell, Kathryn Saatman, Qiang Cheng, and Guoqiang Yu "Noncontact optical assessment of disrupted cerebral functional connectivity in a piglet model of transient ischemic stroke", Proc. SPIE PC11945, Clinical and Translational Neurophotonics 2022, PC1194505 (7 March 2022); https://doi.org/10.1117/12.2609144

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