Quantitative reconstruction of optical absorption coefficient in backward mode photoacoustic imaging

Chao-Kang Liao; Pai-Chi Li

doi:10.1117/12.701725

13 February 2007 Quantitative reconstruction of optical absorption coefficient in backward mode photoacoustic imaging

Chao-Kang Liao, Pai-Chi Li

Proceedings Volume 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; 64371W (2007) https://doi.org/10.1117/12.701725
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

In this paper, an efficient algorithm for quantitative reconstruction of optical absorption coefficient in backward mode photoacoustic imaging is presented. Compared to forward mode and sideward mode (tomographic) imaging, the setup of backward mode imaging generally has a wider range of clinical applications. However, due to the limited detection angles, quantitative image reconstruction has also been difficult. Previously, we proposed a method for reconstruction of optical energy deposition in backward mode imaging. This method is derived from the photoacoustic wave equations with line focusing, with which the focusing is utilized to reduce the reconstruction problem from three dimensions to one dimension. In this paper, we extend the previous reconstruction method for absorbed optical energy to a two-step procedure for optical absorption coefficient. By adding the second step, backward mode photoacoustic imaging becomes more quantitative as the image is directly related to the inherent properties of an image object. In the proposed method, comparison between the reconstructed and the predicted absorbed energy is then iteratively performed to find the optical absorption distribution. Numerical simulations are conducted to verify efficacy of this method. The errors in reconstructed optical absorption coefficient are generally within 10%. Phantom experiments are also performed. The results are presented with a discussion on effects of object position and geometry.

Citation Download Citation

Chao-Kang Liao and Pai-Chi Li "Quantitative reconstruction of optical absorption coefficient in backward mode photoacoustic imaging", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64371W (13 February 2007); https://doi.org/10.1117/12.701725

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