Depth-resolved birefringence imaging of the primate retinal nerve fiber layer using polarization-sensitive OCT

Nathaniel Joseph Kemp; Jesung Park; Jason D. Marsack; Digant P. Dave; Sapun H. Parekh; Thomas E. Milner; Henry Grady Rylander III

doi:10.1117/12.470599

13 June 2002 Depth-resolved birefringence imaging of the primate retinal nerve fiber layer using polarization-sensitive OCT

Nathaniel Joseph Kemp, Jesung Park, Jason D. Marsack, Digant P. Dave, Sapun H. Parekh, Thomas E. Milner, Henry Grady Rylander III

Author Affiliations +

Proceedings Volume 4611, Ophthalmic Technologies XII; (2002) https://doi.org/10.1117/12.470599
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Imaging the optical phase retardation per unit depth (OPR/UD) in the retinal nerve fiber layer (RNFL) may aid in glaucoma diagnosis. Polarization Sensitive Optical Coherence Tomography (PSOCT) was used to record in vivo high-resolution images of the RNFL in two cynomologous monkeys. The depth variation in the Stokes vector of reflected light was used to calculate the OPR/UD as a function of RNFL position. OPR/UD decreased from 35 degree(s)/100 micrometers near the optic nerve to 5 degree(s)/100 micrometers at a location 600 micrometers superior to the optic nerve. Variation of OPR/UD in the RNFL with retinal position demonstrates a change in birefringence for different densities of ganglion cell axons. PSOCT may be useful for noninvasive determination of RNFL thickness and fiber density.

Citation Download Citation

Nathaniel Joseph Kemp, Jesung Park, Jason D. Marsack, Digant P. Dave, Sapun H. Parekh, Thomas E. Milner, and Henry Grady Rylander III "Depth-resolved birefringence imaging of the primate retinal nerve fiber layer using polarization-sensitive OCT", Proc. SPIE 4611, Ophthalmic Technologies XII, (13 June 2002); https://doi.org/10.1117/12.470599

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