Carbon dioxide reactivity of tumor blood flow as measured by dynamic contrast-enhanced computed tomography: a new treatment protocol for laser thermal therapy

Thomas G. Purdie; Michael D. Sherar; Aaron Fenster; Ting-Yim Lee

doi:10.1117/12.428122

21 May 2001 Carbon dioxide reactivity of tumor blood flow as measured by dynamic contrast-enhanced computed tomography: a new treatment protocol for laser thermal therapy

Thomas G. Purdie, Michael D. Sherar, Aaron Fenster, Ting-Yim Lee

Author Affiliations +

Proceedings Volume 4321, Medical Imaging 2001: Physiology and Function from Multidimensional Images; (2001) https://doi.org/10.1117/12.428122
Event: Medical Imaging 2001, 2001, San Diego, CA, United States

Abstract

The purpose of the current study is to measure the carbon dioxide reactivity of blood flow in VX2 tumor in the rabbit thigh. The carbon dioxide reactivity of the functional parameters was investigated in eight rabbits by changing the ventilation rate in order to manipulate the arterial carbon dioxide tension (P_aCO₂). In each experiment, functional maps were generated at four P_aCO₂ levels: normocapnia (P_aCO₂ equals 40.7 +/- 1.4 mm Hg), hypocapnia (27.1 +/- 2.5 and 33.7 +/- 2.2) and hypercapnia (53.8 +/- 5.2). The carbon dioxide reactivity of tumor blood flow showed significant differences between normocapnia and the two levels of hypocapnia, but not between normocapnia and hypercapnia. The average fractional change of blood flow from normocapnia for the two hypocapnic level was -0.41 +/- 0.06 and -0.29 +/- 0.08, respectively. The ability to reduce blood flow through hypocapnia has significant implications in thermal therapy, as heat dissipation represents a major obstacle which limits the effectiveness of treatment.

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Thomas G. Purdie, Michael D. Sherar, Aaron Fenster, and Ting-Yim Lee "Carbon dioxide reactivity of tumor blood flow as measured by dynamic contrast-enhanced computed tomography: a new treatment protocol for laser thermal therapy", Proc. SPIE 4321, Medical Imaging 2001: Physiology and Function from Multidimensional Images, (21 May 2001); https://doi.org/10.1117/12.428122

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