Simulation study of Compton scatter recovery in an ultra-high-performance brain PET scanner with onion ring geometry

Andrzej Krol; Eric S. Harmon; Michael O. Thompson; Ross Schmidtlein

doi:10.1117/12.3009701

3 April 2024 Simulation study of Compton scatter recovery in an ultra-high-performance brain PET scanner with onion ring geometry

Andrzej Krol, Eric S. Harmon, Michael O. Thompson, Ross Schmidtlein

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Proceedings Volume 12930, Medical Imaging 2024: Clinical and Biomedical Imaging; 1293012 (2024) https://doi.org/10.1117/12.3009701
Event: SPIE Medical Imaging, 2024, San Diego, California, United States

Abstract

Our goal is development of an innovative brain-PET with effective sensitivity (8X) and higher spatial resolution vs. current advanced brain-PET systems by implementation of advanced ultrafast SiPM/readout systems coupled to thin monolithic crystals arranged in “onion ring” geometry with small air-gaps between the rings enabling accurate tracking of Compton Scatter (CS) events followed by photoelectric absorption (PE) events, forming “triplets” (PE =CS-PE). We performed Monte Carlo simulations of four concentric rings with diameters 250, 270, 290, 310 mm, and 508 mm axial length with monolithic 3-mm-thick LYSO thin-slab detector modules. The brain was simulated by a water sphere containing F-18. We considered only true-coincidence (PE=PE) and triplet (PE =CS-PE) events. For triplets, back-to-forward scatter ratio is 0.26. The triplet-to-true-coincidence events ratio is 0.30. Inclusion of triplets in addition to true-coincidence events allows sensitivity increase by ~30%. Because the point-of-first interaction is well defined, the improved spatial resolution is anticipated.

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Andrzej Krol, Eric S. Harmon, Michael O. Thompson, and Ross Schmidtlein "Simulation study of Compton scatter recovery in an ultra-high-performance brain PET scanner with onion ring geometry", Proc. SPIE 12930, Medical Imaging 2024: Clinical and Biomedical Imaging, 1293012 (3 April 2024); https://doi.org/10.1117/12.3009701

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KEYWORDS

Monte Carlo methods

Brain

Positron emission tomography

Neuroimaging

Scanners

Crystals

Imaging systems

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