O-pH preliminary report: first-in-human clinical testing of oral biofilm pH using a non-contact optical probe

Manuja Sharma; Lauren K. Lee; Matthew D. Carson; David S. Park; Se Won An; Micah G. Bovenkamp; Jess J. Cayetano; Ian A. Berude; Zheng Xu; Alireza Sadr; Shwetak N. Patel; Eric J. Seibel

doi:10.1117/12.2579088

5 March 2021 O-pH preliminary report: first-in-human clinical testing of oral biofilm pH using a non-contact optical probe

Manuja Sharma, Lauren K. Lee, Matthew D. Carson, David S. Park, Se Won An, Micah G. Bovenkamp, Jess J. Cayetano, Ian A. Berude, Zheng Xu, Alireza Sadr, Shwetak N. Patel, Eric J. Seibel

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Proceedings Volume 11627, Photonic Therapeutics and Diagnostics in Dentistry, Head and Neck Surgery, and Otolaryngology; 116270J (2021) https://doi.org/10.1117/12.2579088
Event: SPIE BiOS, 2021, Online Only

Abstract

Measuring the activity of oral-bacteria in plaque, the sticky biofilm on enamel, can provide the presently lacking oral feedback to patients. We have developed O-pH, optical pH monitor that measures pH in the range of 4-7.5 and tested in vivo on 25 pediatric subjects (10-18 years) with high caries risk, 18 of these subjects had a dental cleaning within last two months and 7 didn’t have a cleaning in over 2 months. The average pH after a sugar rinse from regions of biofilm associated with caries was 5.8 and 0.5 units lower than the biofilm of sound enamel.

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Manuja Sharma, Lauren K. Lee, Matthew D. Carson, David S. Park, Se Won An, Micah G. Bovenkamp, Jess J. Cayetano, Ian A. Berude, Zheng Xu, Alireza Sadr, Shwetak N. Patel, and Eric J. Seibel "O-pH preliminary report: first-in-human clinical testing of oral biofilm pH using a non-contact optical probe", Proc. SPIE 11627, Photonic Therapeutics and Diagnostics in Dentistry, Head and Neck Surgery, and Otolaryngology, 116270J (5 March 2021); https://doi.org/10.1117/12.2579088

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KEYWORDS

Bacteria

Dental caries

Luminescence

In vivo imaging

Light emitting diodes

Measurement devices

Optical testing

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