Characterization of erythrocyte stasis in the human eye using adaptive optics erythrocyte-mediated angiography

Joanne Li; Andrew J. Bower; Jessica Pottenburgh; Samuel Asanad; Laryssa A. Huryn; Osamah J. Saeedi; Johnny Tam

doi:10.1117/12.2577857

5 March 2021 Characterization of erythrocyte stasis in the human eye using adaptive optics erythrocyte-mediated angiography

Joanne Li, Andrew J. Bower, Jessica Pottenburgh, Samuel Asanad, Laryssa A. Huryn, Osamah J. Saeedi, Johnny Tam

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Proceedings Volume 11623, Ophthalmic Technologies XXXI; 116230I (2021) https://doi.org/10.1117/12.2577857
Event: SPIE BiOS, 2021, Online Only

Abstract

Transient stoppage of erythrocytes through different vascular beds has important implications for local tissue metabolism. By combining adaptive optics retinal imaging with erythrocyte-mediated angiography (AO-EMA), erythrocyte stasis events can be readily observed in the microvasculature of living human eyes. Localization of erythrocyte stasis using EMA alongside AO-based indocyanine green (ICG) angiography illustrate the notion that there is a previously uncharacterized population of erythrocytes in stasis residing in the smallest choroidal vessels. These observations are an important step towards elucidating the hemodynamic properties of the choroidal microcirculation and demonstrate a novel application of ICG imaging.

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Joanne Li, Andrew J. Bower, Jessica Pottenburgh, Samuel Asanad, Laryssa A. Huryn, Osamah J. Saeedi, and Johnny Tam "Characterization of erythrocyte stasis in the human eye using adaptive optics erythrocyte-mediated angiography", Proc. SPIE 11623, Ophthalmic Technologies XXXI, 116230I (5 March 2021); https://doi.org/10.1117/12.2577857

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KEYWORDS

Adaptive optics

Angiography

Eye

Liquids

Luminescence

Macula

Mode conditioning cables

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