Biomedical Applications in Molecular, Structural, and Functional Imaging

Preclinical imaging of iridocorneal angle and fundus using a modified integrated flexible handheld probe

[+] Author Affiliations
Xun Jie Jeesmond Hong, Vengalathunadakal K. Shinoj, Vadakke Matham Murukeshan

Nanyang Technological University, Centre for Optical and Laser Engineering, School of Mechanical and Aerospace Engineering, Singapore

Mani Baskaran

Singapore Eye Research Institute and Singapore National Eye Centre, Singapore

Duke-NUS Medicine School, EYE-ACP, Singapore

Tin Aung

Singapore Eye Research Institute and Singapore National Eye Centre, Singapore

Duke-NUS Medicine School, EYE-ACP, Singapore

Yong Loo Lin School of Medicine, Department of Ophthalmology, Singapore

J. Med. Imag. 4(2), 026001 (Apr 10, 2017). doi:10.1117/1.JMI.4.2.026001
History: Received January 25, 2017; Accepted March 21, 2017
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Abstract.  A flexible handheld imaging probe consisting of a 3  mm×3  mm charge-coupled device camera, light-emitting diode light sources, and near-infrared laser source is designed and developed. The imaging probe is designed with specifications to capture the iridocorneal angle images and posterior segment images. Light propagation from the anterior chamber of the eye to the exterior is considered analytically using Snell’s law. Imaging of the iridocorneal angle region and fundus is performed on ex vivo porcine samples and subsequently on small laboratory animals, such as the New Zealand white rabbit and nonhuman primate, in vivo. The integrated flexible handheld probe demonstrates high repeatability in iridocorneal angle and fundus documentation. The proposed concept and methodology are expected to find potential application in the diagnosis, prognosis, and management of glaucoma.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Xun Jie Jeesmond Hong ; Vengalathunadakal K. Shinoj ; Vadakke Matham Murukeshan ; Mani Baskaran and Tin Aung
"Preclinical imaging of iridocorneal angle and fundus using a modified integrated flexible handheld probe", J. Med. Imag. 4(2), 026001 (Apr 10, 2017). ; http://dx.doi.org/10.1117/1.JMI.4.2.026001


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