Special Section on Development, Challenges, and Opportunities of Positron Emission Tomography

New-generation small animal positron emission tomography system for molecular imaging

[+] Author Affiliations
Shiva Abbaszadeh

Stanford University School of Medicine, Department of Radiology, 300 Pasteur Drive, MC 5128, Alway Building, Room M001, Stanford, California 94035, United States

Craig S. Levin

Stanford University School of Medicine, Department of Radiology, 300 Pasteur Drive, MC 5128, Alway Building, Room M001, Stanford, California 94035, United States

Stanford University School of Medicine, Department of Physics, 300 Pasteur Drive, MC 5128, Alway Building, Room M001, Stanford, California 94035, United States

Stanford University School of Medicine, Department of Electrical Engineering, 300 Pasteur Drive, MC 5128, Alway Building, Room M001, Stanford, California 94035, United States

Stanford University School of Medicine, Department of Bioengineering, 300 Pasteur Drive, MC 5128, Alway Building, Room M001, Stanford, California 94035, United States

J. Med. Imag. 4(1), 011008 (Jan 12, 2017). doi:10.1117/1.JMI.4.1.011008
History: Received July 30, 2016; Accepted December 27, 2016
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Abstract.  The next generation of discoveries in molecular imaging requires positron emission tomography (PET) systems with high spatial resolution and high sensitivity to visualize and quantify low concentrations of molecular probes. The goal of this work is to assemble and explore such a system. We use cadmium zinc telluride (CZT) to achieve high spatial resolution, three-dimensional interaction positioning, and excellent energy resolution. The CZT crystals are arranged in an edge-on configuration with a minimum gap of 50  μm in a four-sided panel geometry to achieve superior photon sensitivity. The developed CZT detectors and readout electronics were scaled up to complete significant portions of the final PET system. The steering electrode bias and the amplitude of the analog signals for time measurement were optimized to improve performance. The energy resolution (at 511 keV) over 468 channels is 7.43±1.02% full-width-at-half-maximum (FWHM). The spatial resolution is 0.76±0.1  mm FWHM. The time resolution of six CZT crystals in coincidence with six other CZT crystals is 37 ns. With high energy and spatial resolution and the relatively low random rate for small animal imaging, this system shows promise to be very useful for molecular imaging studies.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Shiva Abbaszadeh and Craig S. Levin
"New-generation small animal positron emission tomography system for molecular imaging", J. Med. Imag. 4(1), 011008 (Jan 12, 2017). ; http://dx.doi.org/10.1117/1.JMI.4.1.011008


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