Special Section on Development, Challenges, and Opportunities of Positron Emission Tomography

INSIDE in-beam positron emission tomography system for particle range monitoring in hadrontherapy

[+] Author Affiliations
Maria Giuseppina Bisogni, Nicola Belcari, Niccolo’ Camarlinghi, Alberto Del Guerra, Matteo Morrocchi, Maria Antonietta Piliero, Giovanni Pirrone, Valeria Rosso, Giancarlo Sportelli

University of Pisa, Department of Physics, Largo B. Pontecorvo 3, 56127 Pisa, Italy

Istituto Nazionale Fisica Nucleare INFN, Sezione di Pisa, Largo B. Pontecorvo 3, 56127 Pisa, Italy

Andrea Attili, Veronica Ferrero, Cristiana Peroni

University of Torino, Department of Physics, Via Pietro Giuria 1, 10125, Torino, Italy

Istituto Nazionale Fisica Nucleare INFN, Sezione di Torino, Via Pietro Giuria 1, 10125, Torino, Italy

Giuseppe Battistoni, Paola Sala

Istituto Nazionale Fisica Nucleare INFN, Sezione di Milano, Via Celoria 16, 20133, Milano, Italy

Piergiorgio Cerello, Silvia Coli, Elisa Fiorina, Giuseppe Giraudo, Francesco Pennazio, Angelo Rivetti, Manuel D. Rolo, Richard Wheadon

Istituto Nazionale Fisica Nucleare INFN, Sezione di Torino, Via Pietro Giuria 1, 10125, Torino, Italy

Alfredo Ferrari

Organisation Européenne pour la Recherche Nucléaire CERN, CH-1211, Geneva 23, Switzerland

Eleftheria Kostara

Istituto Nazionale Fisica Nucleare INFN, Sezione di Pisa, Largo B. Pontecorvo 3, 56127 Pisa, Italy

J. Med. Imag. 4(1), 011005 (Dec 02, 2016). doi:10.1117/1.JMI.4.1.011005
History: Received July 29, 2016; Accepted November 15, 2016
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Abstract.  The quality assurance of particle therapy treatment is a fundamental issue that can be addressed by developing reliable monitoring techniques and indicators of the treatment plan correctness. Among the available imaging techniques, positron emission tomography (PET) has long been investigated and then clinically applied to proton and carbon beams. In 2013, the Innovative Solutions for Dosimetry in Hadrontherapy (INSIDE) collaboration proposed an innovative bimodal imaging concept that combines an in-beam PET scanner with a tracking system for charged particle imaging. This paper presents the general architecture of the INSIDE project but focuses on the in-beam PET scanner that has been designed to reconstruct the particles range with millimetric resolution within a fraction of the dose delivered in a treatment of head and neck tumors. The in-beam PET scanner has been recently installed at the Italian National Center of Oncologic Hadrontherapy (CNAO) in Pavia, Italy, and the commissioning phase has just started. The results of the first beam test with clinical proton beams on phantoms clearly show the capability of the in-beam PET to operate during the irradiation delivery and to reconstruct on-line the beam-induced activity map. The accuracy in the activity distal fall-off determination is millimetric for therapeutic doses.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Maria Giuseppina Bisogni ; Andrea Attili ; Giuseppe Battistoni ; Nicola Belcari ; Niccolo’ Camarlinghi, et al.
"INSIDE in-beam positron emission tomography system for particle range monitoring in hadrontherapy", J. Med. Imag. 4(1), 011005 (Dec 02, 2016). ; http://dx.doi.org/10.1117/1.JMI.4.1.011005


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