Special Section on Development, Challenges, and Opportunities of Positron Emission Tomography

Evaluation of lesion detectability in positron emission tomography when using a convergent penalized likelihood image reconstruction method

[+] Author Affiliations
Kristen A. Wangerin

General Electric Global Research Center, 1 Research Circle, Niskayuna, New York 12309, United States

University of Washington, Department of Bioengineering, 3720 15th Avenue NE, Seattle, Washington 98195, United States

Sangtae Ahn, Ravindra M. Manjeshwar

General Electric Global Research Center, 1 Research Circle, Niskayuna, New York 12309, United States

Scott Wollenweber, Steven G. Ross

General Electric Healthcare, 3000 North Grandview Boulevard, Waukesha, Wisconsin 53188, United States

Paul E. Kinahan

University of Washington, Department of Bioengineering, 3720 15th Avenue NE, Seattle, Washington 98195, United States

University of Washington, Department of Radiology, 1959 NE Pacific Street, Seattle, Washington 98195, United States

J. Med. Imag. 4(1), 011002 (Nov 22, 2016). doi:10.1117/1.JMI.4.1.011002
History: Received June 24, 2016; Accepted October 18, 2016
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Abstract.  We have previously developed a convergent penalized likelihood (PL) image reconstruction algorithm using the relative difference prior (RDP) and showed that it achieves more accurate lesion quantitation compared to ordered subsets expectation maximization (OSEM). We evaluated the detectability of low-contrast liver and lung lesions using the PL-RDP algorithm compared to OSEM. We performed a two-alternative forced choice study using a channelized Hotelling observer model that was previously validated against human observers. Lesion detectability showed a stronger dependence on lesion size for PL-RDP than OSEM. Lesion detectability was improved using time-of-flight (TOF) reconstruction, with greater benefit for the liver compared to the lung and with increasing benefit for decreasing lesion size and contrast. PL detectability was statistically significantly higher than OSEM for 20 mm liver lesions when contrast was 0.5 (p<0.05), and TOF PL detectability was statistically significantly higher than TOF OSEM for 15 and 20 mm liver lesions with contrast 0.5 and 0.25, respectively. For all other cases, there was no statistically significant difference between PL and OSEM (p>0.05). For the range of studied lesion properties, lesion detectability using PL-RDP was equivalent or improved compared to using OSEM.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Kristen A. Wangerin ; Sangtae Ahn ; Scott Wollenweber ; Steven G. Ross ; Paul E. Kinahan, et al.
"Evaluation of lesion detectability in positron emission tomography when using a convergent penalized likelihood image reconstruction method", J. Med. Imag. 4(1), 011002 (Nov 22, 2016). ; http://dx.doi.org/10.1117/1.JMI.4.1.011002


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