Computer-Aided Diagnosis

Digital mammographic tumor classification using transfer learning from deep convolutional neural networks

[+] Author Affiliations
Benjamin Q. Huynh, Hui Li, Maryellen L. Giger

University of Chicago, Department of Radiology, 5841 South Maryland Avenue, Chicago, Illinois 60637, United States

J. Med. Imag. 3(3), 034501 (Aug 22, 2016). doi:10.1117/1.JMI.3.3.034501
History: Received February 11, 2016; Accepted August 1, 2016
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Abstract.  Convolutional neural networks (CNNs) show potential for computer-aided diagnosis (CADx) by learning features directly from the image data instead of using analytically extracted features. However, CNNs are difficult to train from scratch for medical images due to small sample sizes and variations in tumor presentations. Instead, transfer learning can be used to extract tumor information from medical images via CNNs originally pretrained for nonmedical tasks, alleviating the need for large datasets. Our database includes 219 breast lesions (607 full-field digital mammographic images). We compared support vector machine classifiers based on the CNN-extracted image features and our prior computer-extracted tumor features in the task of distinguishing between benign and malignant breast lesions. Five-fold cross validation (by lesion) was conducted with the area under the receiver operating characteristic (ROC) curve as the performance metric. Results show that classifiers based on CNN-extracted features (with transfer learning) perform comparably to those using analytically extracted features [area under the ROC curve (AUC)=0.81]. Further, the performance of ensemble classifiers based on both types was significantly better than that of either classifier type alone (AUC=0.86 versus 0.81, p=0.022). We conclude that transfer learning can improve current CADx methods while also providing standalone classifiers without large datasets, facilitating machine-learning methods in radiomics and precision medicine.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Benjamin Q. Huynh ; Hui Li and Maryellen L. Giger
"Digital mammographic tumor classification using transfer learning from deep convolutional neural networks", J. Med. Imag. 3(3), 034501 (Aug 22, 2016). ; http://dx.doi.org/10.1117/1.JMI.3.3.034501


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