Physics of Medical Imaging

High spatial resolution diffusion weighted imaging on clinical 3 T MRI scanners using multislab spiral acquisitions

[+] Author Affiliations
Joseph L. Holtrop, Bradley P. Sutton

University of Illinois at Urbana-Champaign, Department of Bioengineering, 1270 Digital Computer Laboratory, MC-278, Urbana, Illinois 61801, United States

University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, 405 North Mathews, MC-251, Urbana, Illinois 61801, United States

J. Med. Imag. 3(2), 023501 (Apr 12, 2016). doi:10.1117/1.JMI.3.2.023501
History: Received December 15, 2015; Accepted March 14, 2016
Text Size: A A A

Abstract.  A diffusion weighted imaging (DWI) approach that is signal-to-noise ratio (SNR) efficient and can be applied to achieve sub-mm resolutions on clinical 3 T systems was developed. The sequence combined a multislab, multishot pulsed gradient spin echo diffusion scheme with spiral readouts for imaging data and navigators. Long data readouts were used to keep the number of shots, and hence total imaging time, for the three-dimensional acquisition short. Image quality was maintained by incorporating a field-inhomogeneity-corrected image reconstruction to remove distortions associated with long data readouts. Additionally, multiple shots were required for the high-resolution images, necessitating motion induced phase correction through the use of efficiently integrated navigator data. The proposed approach is compared with two-dimensional (2-D) acquisitions that use either a spiral or a typical echo-planar imaging (EPI) acquisition to demonstrate the improved SNR efficiency. The proposed technique provided 71% higher SNR efficiency than the standard 2-D EPI approach. The adaptability of the technique to achieve high spatial resolutions is demonstrated by acquiring diffusion tensor imaging data sets with isotropic resolutions of 1.25 and 0.8 mm. The proposed approach allows for SNR-efficient sub-mm acquisitions of DWI data on clinical 3 T systems.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Joseph L. Holtrop and Bradley P. Sutton
"High spatial resolution diffusion weighted imaging on clinical 3 T MRI scanners using multislab spiral acquisitions", J. Med. Imag. 3(2), 023501 (Apr 12, 2016). ; http://dx.doi.org/10.1117/1.JMI.3.2.023501


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.