Biomedical Applications in Molecular, Structural, and Functional Imaging

Automated working distance adjustment enables optical coherence tomography of the human larynx in awake patients

[+] Author Affiliations
Sabine Donner, Sebastian Bleeker, Tammo Ripken, Alexander Krueger

Laser Zentrum Hannover e.V., Biomedical Optics Department, Hollerithallee 8, 30419 Hannover, Germany

Martin Ptok, Michael Jungheim

Hannover Medical School, Clinic for Phoniatry and Paediatric Audiology, Carl-Neuberg-Street 1, 30625 Hannover, Germany

J. Med. Imag. 2(2), 026003 (Jun 25, 2015). doi:10.1117/1.JMI.2.2.026003
History: Received October 24, 2014; Accepted May 20, 2015
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Abstract.  Optical coherence tomography (OCT) provides structural information of laryngeal tissue which is comparable to histopathological analysis of biopsies taken under general anesthesia. In awake patients, movements impede clinically useful OCT acquisition. Therefore, an automatic compensation of movements was implemented into a swept source OCT-laryngoscope. Video and OCT beam path were combined in one tube of 10-mm diameter. Segmented OCT images served as distance sensor and a feedback control adjusted the working distance between 33 and 70 mm by synchronously translating the reference mirror and focusing lens. With this motion compensation, the tissue was properly visible in up to 88% of the acquisition time. During quiet respiration, OCT contrasted epithelium and lamina propria. Mean epithelial thickness was measured to be 109 and 135μm in female and male, respectively. Furthermore, OCT of mucosal wave movements during phonation enabled estimation of the oscillation frequency and amplitude. Regarding clinical issues, the OCT-laryngoscope with automated working distance adjustment may support the estimation of the depth extent of epithelial lesions and contribute to establish an indication for a biopsy. Moreover, OCT of the vibrating vocal folds provides functional information, possibly giving further insight into mucosal behavior during the vibratory cycle.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Sabine Donner ; Sebastian Bleeker ; Tammo Ripken ; Martin Ptok ; Michael Jungheim, et al.
"Automated working distance adjustment enables optical coherence tomography of the human larynx in awake patients", J. Med. Imag. 2(2), 026003 (Jun 25, 2015). ; http://dx.doi.org/10.1117/1.JMI.2.2.026003


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