Image Perception, Observer Performance, and Technology Assessment

Mammographic density measurements are not affected by mammography system

[+] Author Affiliations
Christine N. Damases

University of Sydney, Faculty of Health Sciences, Discipline of Medical Radiation Sciences and Brain and Mind Research Institute, M205, Cumberland Campus, East Street, Lidcombe, New South Wales 2141, Sydney

University of Namibia, Faculty of Health Sciences, Department of Allied Sciences, M-Block, Room M-105, Mandume Ndemufayo Avenue, Private bag 13310, Windhoek 9000, Namibia

Patrick C. Brennan, Mark F. McEntee

University of Sydney, Faculty of Health Sciences, Discipline of Medical Radiation Sciences and Brain and Mind Research Institute, M205, Cumberland Campus, East Street, Lidcombe, New South Wales 2141, Sydney

J. Med. Imag. 2(1), 015501 (Mar 04, 2015). doi:10.1117/1.JMI.2.1.015501
History: Received October 22, 2014; Accepted February 5, 2015
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Abstract.  Mammographic density (MD) is a significant risk factor for breast cancer and has been shown to reduce the sensitivity of mammography screening. Knowledge of a woman’s density can be used to predict her risk of developing breast cancer and personalize her imaging pathway. However, measurement of breast density has proven to be troublesome with wide variations in density recorded using radiologists’ visual Breast Imaging Reporting and Data System (BIRADS). Several automated methods for assessing breast density have been proposed, each with their own source of measurement error. The use of differing mammographic imaging systems further complicates MD measurement, especially for the same women imaged over time. The purpose of this study was to investigate whether having a mammogram on differing manufacturer’s equipment affects a woman’s MD measurement. Raw mammographic images were acquired on two mammography imaging systems (General Electric and Hologic) one year apart and processed using VolparaDensity™ to obtain the Volpara Density Grade (VDG) and average volumetric breast density percentage (AvBD%). Visual BIRADS scores were also obtained from 20 expert readers. BIRADS scores for both systems showed strong positive correlation (ρ=0.904; p<0.001), while the VDG (ρ=0.978; p<0.001) and AvBD% (ρ=0.973; p<0.001) showed stronger positive correlations. Substantial agreement was shown between the systems for BIRADS (κ=0.692; p<0.001), however, the systems demonstrated an almost perfect agreement for VDG (κ=0.933; p<0.001).

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Christine N. Damases ; Patrick C. Brennan and Mark F. McEntee
"Mammographic density measurements are not affected by mammography system", J. Med. Imag. 2(1), 015501 (Mar 04, 2015). ; http://dx.doi.org/10.1117/1.JMI.2.1.015501


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