Physics of Medical Imaging

Optimization of contrast-enhanced spectral mammography depending on clinical indication

[+] Author Affiliations
Clarisse Dromain

Institut de Cancérologie Gustave Roussy, Department of Radiology, 114, Rue Edouard Vaillant 94805 Villejuif Cedex, France

Sandra Canale

Institut de Cancérologie Gustave Roussy, Department of Radiology, 114, Rue Edouard Vaillant 94805 Villejuif Cedex, France

Sylvie Saab-Puong, Ann-Katherine Carton, Serge Muller

GE Healthcare, 283 rue de la Minière, 78530 Buc, France

Eva Maria Fallenberg

University Hospital Charite, Department of Radiology, Berlin, Germany

J. Med. Imag. 1(3), 033506 (Dec 30, 2014). doi:10.1117/1.JMI.1.3.033506
History: Received June 25, 2014; Accepted November 24, 2014
Text Size: A A A

Abstract.  The objective is to optimize low-energy (LE) and high-energy (HE) exposure parameters of contrast-enhanced spectral mammography (CESM) examinations in four different clinical applications for which different levels of average glandular dose (AGD) and ratios between LE and total doses are required. The optimization was performed on a Senographe DS with a SenoBright® upgrade. Simulations were performed to find the optima by maximizing the contrast-to-noise ratio (CNR) on the recombined CESM image using different targeted doses and LE image quality. The linearity between iodine concentration and CNR as well as the minimal detectable iodine concentration was assessed. The image quality of the LE image was assessed on the CDMAM contrast-detail phantom. Experiments confirmed the optima found on simulation. The CNR was higher for each clinical indication than for SenoBright®, including the screening indication for which the total AGD was 22% lower. Minimal iodine concentrations detectable in the case of a 3-mm-diameter round tumor were 12.5% lower than those obtained for the same dose in the clinical routine. LE image quality satisfied EUREF acceptable limits for threshold contrast. This newly optimized set of acquisition parameters allows increased contrast detectability compared to parameters currently used without a significant loss in LE image quality.

Figures in this Article
© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Clarisse Dromain ; Sandra Canale ; Sylvie Saab-Puong ; Ann-Katherine Carton ; Serge Muller, et al.
"Optimization of contrast-enhanced spectral mammography depending on clinical indication", J. Med. Imag. 1(3), 033506 (Dec 30, 2014). ; http://dx.doi.org/10.1117/1.JMI.1.3.033506


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.