Mechanical stability analysis of carrageenan-based polymer gel for magnetic resonance imaging liver phantom with lesion particles

Eunji In; Hani E. Naguib; Masoom Haider

doi:10.1117/1.JMI.1.3.035502

19 December 2014 Mechanical stability analysis of carrageenan-based polymer gel for magnetic resonance imaging liver phantom with lesion particles

Eunji In, Hani E. Naguib, Masoom Haider

Author Affiliations +

Journal of Medical Imaging, Vol. 1, Issue 3, 035502 (December 2014). https://doi.org/10.1117/1.JMI.1.3.035502

Abstract

Medical imaging is an effective technique used to detect and prevent disease in cancer research. To optimize medical imaging, a calibration medium or phantom with tissue-mimicking properties is required. Although the feasibility of various polymer gel materials has previously been studied, the stability of the gels’ properties has not been investigated. In this study, we fabricated carrageenan-based polymer gel to examine the stability of its properties such as density, conductivity, permittivity, elastic modulus, and T₁ and T₂ relaxation times over six weeks. We fabricated eight samples with different carrageenan and agar concentrations and found that the density, elastic modulus, and compressive strength fluctuated with no specific pattern. The elastic modulus in sample 4 with 3 wt. % carrageenan and 1.5 wt. % agar fluctuated from 0.51 to 0.64 MPa in five weeks. The T₁ and T₂ relaxation times also varied by 23% to 29%. We believe that the fluctuation of these properties is related to the change in water content of the sample due to cycles of water expulsion and absorption in their containers. The fluctuation of the properties should be minimized to achieve accurate calibration over the shelf life of the phantom and to serve as the standard for quality assurance. Furthermore, a full liver phantom with spherical lesion particles was fabricated to demonstrate the potential for phantom production.

Citation Download Citation

Eunji In, Hani E. Naguib, and Masoom Haider "Mechanical stability analysis of carrageenan-based polymer gel for magnetic resonance imaging liver phantom with lesion particles," Journal of Medical Imaging 1(3), 035502 (19 December 2014). https://doi.org/10.1117/1.JMI.1.3.035502

Published: 19 December 2014

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