Physics of Medical Imaging

Calibration-free coronary artery measurements for interventional device sizing using inverse geometry x-ray fluoroscopy: in vivo validation

[+] Author Affiliations
Michael T. Tomkowiak

University of Wisconsin-Madison, Department of Medical Physics, 1111 Highland Avenue, Madison, Wisconsin 53705, United States

Amish N. Raval

University of Wisconsin-Madison, Department of Medicine, 600 Highland Avenue, Madison, Wisconsin 53792, United States

Michael S. Van Lysel, Michael A. Speidel

University of Wisconsin-Madison, Department of Medical Physics, 1111 Highland Avenue, Madison, Wisconsin 53705, United States

University of Wisconsin-Madison, Department of Medicine, 600 Highland Avenue, Madison, Wisconsin 53792, United States

Tobias Funk

Triple Ring Technologies, Inc., 39655 Eureka Drive, Newark, California 94560, United States

J. Med. Imag. 1(3), 033504 (Nov 26, 2014). doi:10.1117/1.JMI.1.3.033504
History: Received April 25, 2014; Accepted October 30, 2014
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Abstract.  Proper sizing of interventional devices to match coronary vessel dimensions improves procedural efficiency and therapeutic outcomes. We have developed a method that uses an inverse geometry x-ray fluoroscopy system [scanning beam digital x-ray (SBDX)] to automatically determine vessel dimensions from angiograms without the need for magnification calibration or optimal views. For each frame period (1/15th of a second), SBDX acquires a sequence of narrow beam projections and performs digital tomosynthesis at multiple plane positions. A three-dimensional model of the vessel is reconstructed by localizing the depth of the vessel edges from the tomosynthesis images, and the model is used to calculate the length and diameter in units of millimeters. The in vivo algorithm performance was evaluated in a healthy porcine model by comparing end-diastolic length and diameter measurements from SBDX to coronary computed tomography angiography (CCTA) and intravascular ultrasound (IVUS), respectively. The length error was 0.49±1.76mm (SBDX – CCTA, mean±1SD). The diameter error was 0.07±0.27mm (SBDX − minimum IVUS diameter, mean±1SD). The in vivo agreement between SBDX-based vessel sizing and gold standard techniques supports the feasibility of calibration-free coronary vessel sizing using inverse geometry x-ray fluoroscopy.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Michael T. Tomkowiak ; Amish N. Raval ; Michael S. Van Lysel ; Tobias Funk and Michael A. Speidel
"Calibration-free coronary artery measurements for interventional device sizing using inverse geometry x-ray fluoroscopy: in vivo validation", J. Med. Imag. 1(3), 033504 (Nov 26, 2014). ; http://dx.doi.org/10.1117/1.JMI.1.3.033504


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