Impact of family structure and common environment on heritability estimation for neuroimaging genetics studies using Sequential Oligogenic Linkage Analysis Routines

Mary Ellen Koran; Tricia A. Thornton-Wells; Neda Jahanshad; David C. Glahn; Paul M. Thompson; John Blangero; Thomas E. Nichols; Peter Kochunov; Bennett A. Landman

doi:10.1117/1.JMI.1.1.014005

27 June 2014 Impact of family structure and common environment on heritability estimation for neuroimaging genetics studies using Sequential Oligogenic Linkage Analysis Routines

Mary Ellen Koran, Tricia A. Thornton-Wells, Neda Jahanshad, David C. Glahn, Paul M. Thompson, John Blangero, Thomas E. Nichols, Peter Kochunov, Bennett A. Landman

Author Affiliations +

Journal of Medical Imaging, Vol. 1, Issue 1, 014005 (June 2014). https://doi.org/10.1117/1.JMI.1.1.014005

Abstract

Imaging genetics is an emerging methodological field that combines genetic information with medical imaging-derived metrics to understand how genetic factors impact observable phenotypes. In order for a trait to be a reasonable phenotype in an imaging genetics study, it must be heritable: at least some proportion of its variance must be due to genetic influences. The Sequential Oligogenic Linkage Analysis Routines (SOLAR) imaging genetics software can estimate the heritability of a trait in complex pedigrees. We investigate the ability of SOLAR to accurately estimate heritability and common environmental effects on simulated imaging phenotypes in various family structures. We found that heritability is reliably estimated with small family-based studies of 40 to 80 individuals, though subtle differences remain between the family structures. In an imaging application analysis, we found that with 80 subjects in any of the family structures, estimated heritability of white matter fractional anisotropy was biased by <10% for every region of interest. Results from these studies can be used when investigators are evaluating power in planning genetic analyzes.

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Mary Ellen Koran, Tricia A. Thornton-Wells, Neda Jahanshad, David C. Glahn, Paul M. Thompson, John Blangero, Thomas E. Nichols, Peter Kochunov, and Bennett A. Landman "Impact of family structure and common environment on heritability estimation for neuroimaging genetics studies using Sequential Oligogenic Linkage Analysis Routines," Journal of Medical Imaging 1(1), 014005 (27 June 2014). https://doi.org/10.1117/1.JMI.1.1.014005

Published: 27 June 2014

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